Defective genes at checkpoints

Defective B cell tolerance checkpoints in systemic lupus erythematosus

A cardinal feature of systemic lupus erythematosus (SLE) is the development of autoantibodies. The first autoantibodies described in patients with SLE were those specific for nuclei and DNA, but subsequent work has shown that individuals with this disease produce a panoply of different autoantibodies. Thus, one of the constant features of SLE is a profound breakdown in tolerance in the antibody...

Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies

Conventional chemotherapeutics target the proliferating fraction of cells in the patient's body, which will include the tumor cells, but are also toxic to actively proliferating normal tissues. Cellular stresses, such as those imposed by chemotherapeutic drugs, induce cell cycle checkpoint arrest, and currently approaches targeting these checkpoints are being explored to increase the efficacy a...

Drinking drivers missed at sobriety checkpoints.

OBJECTIVE Sobriety checkpoints are an effective deterrent to alcohol-impaired driving although a substantial proportion of drinking drivers who pass through checkpoints are missed. The present study was designed to determine the extent to which police officers correctly identify individuals with blood alcohol concentrations (BACs) at or above 0.05% at checkpoints, and if there are characteristi...

Checkpoints

Defective splicing, disease and therapy: searching for master checkpoints in exon definition

The number of aberrant splicing processes causing human disease is growing exponentially and many recent studies have uncovered some aspects of the unexpectedly complex network of interactions involved in these dysfunctions. As a consequence, our knowledge of the various cis- and trans-acting factors playing a role on both normal and aberrant splicing pathways has been enhanced greatly. However...